The BoSox's John Lester, the 23 year old who had his rookie season cut short by a cancer diagnosis, really couldn't have had much of a better return to the majors. Here is his line:
| Boston | IP | H | R | ER | BB | SO | HR | ERA |
| Lester (W, 1-0) | 6.0 | 5 | 2 | 2 | 3 | 6 | 1 | 3.00 |
Welcome back.
The Red Sox won the game 6-2 over Cleveland who still lead the wildcard race.